The Definitive Guide to Fahren lernen Kaiserslautern
The Definitive Guide to Fahren lernen Kaiserslautern
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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor hinein a physiologically häufig pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.
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Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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Together with an interdiziplinary team he uncovered the molecular mechanisms of Alzheimer's disease and identified target molecules for therapeutic treatment.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years Weiterlesen and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the Lager for several current therapeutic approaches.
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Ur learning-type check helps you to learn how to learn more efficiently. Success may Beryllium improved hinein a short time.
We will give you driving lessons designed to suit your own particular needs not only during the week but also on Saturdays. Hinein this way you will get your driving licence as quickly as possible.
Next to the Ostfriedhof bus and tram stop Can I take a trial lesson rein the theoretical course in order to get an impression of the atmosphere?
If you are lacking driving practice or simply haven't driven a car rein a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.